Buy PT-141

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide research compound belonging to the melanocortin receptor agonist family. As a metabolite of Melanotan II, PT-141 has a modified structure that results in a distinct receptor selectivity profile compared to its parent compound. PT-141 selectively targets melanocortin receptors, particularly MC3R and MC4R, with reduced activity at MC1R compared to Melanotan II. This receptor selectivity profile makes PT-141 a valuable tool for researchers studying the melanocortin system's role in various physiological processes.

Quality and Purity Standards

Our PT-141 peptide is manufactured under controlled conditions with ≥99% purity verified by HPLC analysis. Each batch undergoes comprehensive testing, including mass spectrometry for molecular weight confirmation, amino acid analysis for sequence verification, and cyclic peptide structure confirmation. Every order includes a Certificate of Analysis documenting purity levels, identity confirmation, and batch-specific analytical data.

Research Applications and Mechanisms of Action

PT-141 research focuses on melanocortin receptor pharmacology, particularly MC3R and MC4R signaling. The mechanism involves binding to central melanocortin receptors, activating G-protein coupled receptor signaling cascades including cAMP accumulation. Research investigations examine:

MC3R and MC4R binding affinity and selectivity profiling
cAMP signaling pathway activation in melanocortin receptor-expressing cell lines
Central nervous system melanocortin pathway studies in model organisms
Sexual behavior and reproductive physiology research in controlled settings
Melanocortin receptor structure-function relationships

Technical Specifications

Purity: ≥99% (HPLC verified)
Physical Form: Lyophilized powder
Solubility: Soluble in sterile water, saline, or standard research buffers
Storage: -20°C in dry, light-protected conditions
Shelf Life: 24 months from manufacture date

Proper Storage and Handling Guidelines

Store PT-141 lyophilized powder at -20°C in a desiccated, light-protected environment. For reconstitution, use sterile water or 0.9% sodium chloride solution. Store reconstituted solutions at 2–8°C and use within two to four weeks.

Frequently Asked Questions

What is PT-141 used for in research?
PT-141 is a synthetic cyclic heptapeptide melanocortin receptor agonist used in research studying MC3R and MC4R signaling pathways, central melanocortin system function, and related physiological processes.

What purity does PT-141 have?
Our PT-141 is verified at ≥99% purity by HPLC analysis. Each order includes a Certificate of Analysis.

References and Further Reading

Researchers can consult peer-reviewed literature on melanocortin receptor pharmacology (PMID: 14722311, 16919401). All products are for research use only.