Buy Melanotan II

Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂. This research compound belongs to the melanocortin receptor agonist family, a class of peptides that bind to melanocortin receptors (MC1R-MC5R) with varying affinities. Melanotan II represents a significant research tool for investigators studying melanocortin receptor pharmacology, melanogenesis pathways, and the broader physiological roles of the melanocortin system in controlled laboratory settings.

Quality and Purity Standards

Our Melanotan II peptide is manufactured under controlled conditions with ≥99% purity verified by HPLC analysis. Each batch undergoes comprehensive testing, including mass spectrometry for molecular weight confirmation, amino acid analysis for sequence verification, and cyclic peptide structure confirmation. Every order includes a Certificate of Analysis documenting purity levels, identity confirmation, and batch-specific analytical data.

Research Applications and Mechanisms of Action

Melanotan II research focuses on melanocortin receptor pharmacology. The mechanism involves binding to melanocortin receptors (primarily MC1R and MC4R), leading to G-protein coupled receptor activation and cAMP signaling. Research investigations examine:

Melanocortin receptor binding affinity and selectivity profiling across MC1R-MC5R
cAMP accumulation assays in melanocortin receptor-expressing cell lines
Melanogenesis pathway studies in melanocyte cell culture models
Appetitive behavior and energy homeostasis research in model organisms
Sexual behavior and peripheral receptor studies in controlled laboratory settings

Technical Specifications

Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Purity: ≥99% (HPLC verified)
Physical Form: Lyophilized powder
Solubility: Soluble in sterile water, saline, or standard research buffers
Storage: -20°C in dry, light-protected conditions
Shelf Life: 24 months from manufacture date

Proper Storage and Handling Guidelines

Store Melanotan II lyophilized powder at -20°C in a desiccated, light-protected environment. For reconstitution, use sterile water or 0.9% sodium chloride solution. Store reconstituted solutions at 2–8°C and use within two to four weeks.

Frequently Asked Questions

What is Melanotan II used for in research?
Melanotan II is a synthetic cyclic heptapeptide analog of α-MSH used in melanocortin receptor pharmacology research, melanogenesis studies, and investigations of the melanocortin system's physiological roles.

What purity does Melanotan II have?
Our Melanotan II is verified at ≥99% purity by HPLC analysis. Each order includes a Certificate of Analysis.

References and Further Reading

Researchers can consult peer-reviewed literature on melanocortin receptor pharmacology (PMID: 17234609, 16352738). All products are for research use only.