Buy Tesamorelin

Tesamorelin is a synthetic 44-amino acid analog of growth hormone-releasing hormone (GHRH) developed for research into the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. This peptide compound incorporates a trans-3-hexenoic acid moiety at the N-terminus, which enhances its stability and resistance to enzymatic degradation compared to endogenous GHRH. Researchers studying Tesamorelin investigate its effects on pituitary somatotroph function, GH secretion dynamics, and downstream IGF-1 signaling pathways in controlled laboratory settings.

Quality and Purity Standards

Our Tesamorelin peptide is manufactured under controlled conditions with ≥99% purity verified by HPLC analysis. Each batch undergoes comprehensive testing, including mass spectrometry for molecular weight confirmation (approximately 5135 Da), amino acid analysis for sequence verification, and peptide content determination. Every order includes a Certificate of Analysis documenting all analytical results. Our quality control ensures researchers receive Tesamorelin suitable for rigorous investigation.

Research Applications and Mechanisms of Action

Tesamorelin research focuses on its role as a GHRH analog that stimulates growth hormone secretion from anterior pituitary somatotroph cells. The mechanism involves binding to the GHRH receptor (GHRHR), a Class B GPCR, leading to cAMP accumulation and GH gene transcription. Research investigations examine:

GH secretion dynamics in response to GHRH analog stimulation in cell-based assays
IGF-1 production and binding protein modulation in hepatic cell models
GHRH receptor signaling pathways, including cAMP/PKA and MAPK activation
Effects on somatotroph cell function and pituitary hormone regulation
Comparative pharmacology against native GHRH and other GHRH analogs

Technical Specifications

Molecular Weight: ~5135 Da
Amino Acid Length: 44 amino acids
Purity: ≥99% (HPLC verified)
Physical Form: Lyophilized powder
Solubility: Soluble in sterile water, saline, or standard research buffers
Storage: -20°C in dry, light-protected conditions
Shelf Life: 24 months from manufacture date when stored properly

Proper Storage and Handling Guidelines

Store Tesamorelin lyophilized powder at -20°C in a desiccated, light-protected environment. For reconstitution, use sterile water or 0.9% sodium chloride solution and allow 15–30 minutes for complete dissolution. Store reconstituted solutions at 2–8°C and use within two to four weeks. Avoid repeated freeze-thaw cycles to maintain peptide integrity.

Frequently Asked Questions

What is Tesamorelin used for in research?
Tesamorelin is a synthetic GHRH analog used in research to study growth hormone secretion dynamics, somatotroph cell function, and the GH/IGF-1 axis in controlled laboratory settings.

What purity does Tesamorelin have?
Our Tesamorelin is verified at ≥99% purity by HPLC analysis with mass spectrometry confirmation. Each order includes a Certificate of Analysis.

References and Further Reading

Researchers studying the GH/IGF-1 axis can consult peer-reviewed literature on GHRH analogs and somatotroph function (PMID: 15755863, 22048591). All products are for research use only.