Buy GHK-CU

GHK-CU is a copper-binding tripeptide with the sequence Glycyl-L-Histidyl-L-Lysine, naturally occurring in human plasma and capable of binding copper ions with high affinity. This copper-peptide complex has become a significant research compound in cell biology, dermatological research, and tissue remodeling studies. The GHK-CU peptide's ability to chelate copper and deliver it to cellular systems makes it a unique tool for investigating copper-dependent enzymatic processes, including superoxide dismutase activity, lysyl oxidase function, and cytochrome c oxidase regulation. Researchers studying GHK-CU explore its effects on gene expression, cellular signaling, and extracellular matrix dynamics.

Quality and Purity Standards

Our GHK-CU peptide is manufactured under controlled conditions with ≥99% purity verified by HPLC analysis. Each batch undergoes comprehensive testing including mass spectrometry for molecular weight confirmation, amino acid analysis for sequence verification, and copper content determination. Every order includes a Certificate of Analysis documenting purity levels, identity confirmation, and batch-specific analytical data.

Research Applications and Mechanisms of Action

GHK-CU research spans multiple areas of cell biology. The mechanism involves copper delivery to cellular systems, modulating the activity of copper-dependent enzymes and transcription factors. Key research areas include:

Collagen synthesis and extracellular matrix remodeling in fibroblast cell culture models
Copper-dependent enzyme activity studies (superoxide dismutase, lysyl oxidase)
Gene expression profiling of matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs)
Cellular migration and proliferation in dermal cell biology
Antioxidant and anti-inflammatory pathway investigations in cell-based assays

Technical Specifications

Sequence: Gly-His-Lys
Molecular Formula: C₁₄H₂₄N₆O₄·Cu
Molecular Weight: ~403.9 Da (copper complex)
Purity: ≥99% (HPLC verified)
Physical Form: Lyophilized powder
Solubility: Soluble in sterile water, saline, or standard research buffers
Storage: -20°C in dry, light-protected conditions
Shelf Life: 24 months from manufacture date

Proper Storage and Handling Guidelines

Store GHK-CU lyophilized powder at -20°C in a desiccated, light-protected environment. For reconstitution, use sterile water or 0.9% sodium chloride solution. Store reconstituted solutions at 2–8°C and use within two to four weeks. The copper-peptide complex imparts a characteristic blue color to the solution.

Frequently Asked Questions

What is GHK-CU used for in research?
GHK-CU is a copper-binding tripeptide used in cell biology research to study collagen synthesis, extracellular matrix remodeling, copper-dependent enzyme function, and cellular signaling pathways.

What purity does GHK-CU have?
Our GHK-CU is verified at ≥99% purity by HPLC analysis. Each order includes a Certificate of Analysis.

References and Further Reading

Researchers can consult peer-reviewed literature on GHK-CU biology (PMID: 18641098, 29056972). All products are for research use only.