Buy MOTS-C

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a mitochondrial-derived peptide (MDP) encoded by a short open reading frame within the mitochondrial 12S rRNA gene. This 16-amino acid peptide represents a novel class of signaling molecules that originate from the mitochondrial genome and regulate nuclear gene expression. MOTS-c research has garnered significant attention in cellular biology for its role in mitochondrial- nuclear communication, metabolic regulation, and cellular stress responses. Researchers study MOTS-c to understand how mitochondrial peptides influence broader cellular physiology.

Quality and Purity Standards

Our MOTS-c peptide is manufactured under controlled conditions with ≥99% purity verified by HPLC analysis. Each batch undergoes comprehensive testing, including mass spectrometry for molecular weight confirmation (approximately 1965 Da), amino acid sequencing for identity verification, and reverse-phase HPLC for purity assessment. Every order includes a Certificate of Analysis documenting all analytical results. Our quality control protocols ensure researchers receive MOTS-c suitable for advanced cellular and molecular research.

Research Applications and Mechanisms of Action

MOTS-c research focuses on its role as a mitochondrial-derived peptide that translocates to the nucleus to regulate gene expression in response to metabolic stress. The mechanism involves AMPK activation, folate metabolism modulation, and nuclear gene regulation. Key research areas include:

Mitochondrial stress signaling and retrograde communication between mitochondria and nucleus
AMPK pathway activation and its downstream effects on cellular metabolism
Folate metabolism and one-carbon unit regulation in cellular bioenergetics
Insulin sensitivity and glucose metabolism in in vitro cell models
Aging-related cellular changes and mitochondrial dysfunction studies

Technical Specifications

Amino Acid Length: 16 amino acids
Molecular Weight: ~1965 Da
Purity: ≥99% (HPLC verified)
Physical Form: Lyophilized powder
Solubility: Soluble in sterile water, saline, or standard research buffers
Storage: -20°C in dry, light-protected conditions
Shelf Life: 24 months from manufacture date when stored properly

Proper Storage and Handling Guidelines

Store MOTS-c lyophilized powder at -20°C in a desiccated, light-protected environment. For reconstitution, use sterile water or 0.9% sodium chloride solution and allow 15–30 minutes for complete dissolution. Store reconstituted solutions at 2–8°C and use within two to four weeks. Avoid repeated freeze-thaw cycles to maintain peptide stability.

Frequently Asked Questions

What is MOTS-c and why is it important in research?
MOTS-c is a mitochondrial-derived peptide encoded by the mitochondrial 12S rRNA gene. It is important in research because it represents a novel mechanism of mitochondrial-nuclear communication and metabolic regulation.

What purity does MOTS-c have?
Our MOTS-c is verified at ≥99% purity by HPLC analysis with mass spectrometry confirmation. Each order includes a Certificate of Analysis.

References and Further Reading

Researchers studying mitochondrial-derived peptides can consult peer-reviewed literature on MOTS-c biology (PMID: 26321659, 32404333). For additional context, explore our MOTS-c research guide. All products are for research use only.