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MOTS-c

MOTS-c at a glance

Peptide.Express MOTS-c (CAS 1627580-64-6) starts at $45, ≥99% HPLC as the sourcing specification — not a measurement of any one vial — with a molecular weight of 2174.6 Da and molecular formula C101H152N28O22S2; measured purity and mass are only on that lot’s Certificate of Analysis you can verify before purchase. Same-day dispatch on business days (orders before 2 PM EST), free over $150. For in-vitro laboratory research use only.

MOTS-c — research-grade lyophilized peptide vial from Peptide.Express, ≥99% HPLC sourcing specification
≥99% HPLC SpecUS SynthesizedIn Stock

For laboratory research use only. Not for human or veterinary use.

Research-Grade Compound

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino-acid peptide encoded within mitochondrial DNA — specifically translated from a short open reading frame in the 12S ribosomal RNA gene, MT-RNR1. Amino acid sequence: MRWQEMGYIFYPRKLR. Molecular formula C101H152N28O22S2, molecular weight 2,174.6 Da, CAS 1627580-64-6.

Purity standard: MOTS-c is sourced to ≥99% by HPLC — sourcing spec.

1 · Select Size

10mg · $45.00/vial

$45.00$80.00ListUSD / Unit
1

Certificate of Analysis

Showing CoA for 10mg.

Batch PX-L916

HPLC (measured)
99.19%
Sourcing spec (separate line)
≥99% by HPLC
Lot
PX-L916
Accession / CoA number
2609220043
Reported
2026-09-22
Lab
Freedom Diagnostics
View CoAVerify with testing laboratory

See how to read a CoA.

≥99% HPLC SpecSourcing specification
CoA Where On FileThird-party CoA
Ships Same DayBefore 2 PM EST
Free US ShipOrders over $150
MOTS-c mitochondrial peptide research guide →

In-depth research overview, mechanism of action, and study applications.

Showing CoA for 10mg
Certificate DetailsBatch: PX-L916
Batch IDPX-L916
Test DateSeptember 22, 2026
Accession / document id2609220043
Purity (measured)99.19%
Sourcing spec≥99% by HPLC
LotPX-L916
Accession / CoA number2609220043
Reported2026-09-22
LabFreedom Diagnostics
Methodology
HPLCLC-MS/MS
Verify Results with Testing Laboratory

Issued by an independent third-party laboratory; Peptide.Express does not test in-house. Results are reproduced as-is and confirm compound identity, purity, and the analytical methods used. For questions about specific results, contact support@peptide.express.

Safety Data Sheet (SDS)
Catalog identity reference

Theoretical identity from the catalog or verified registry record — not a laboratory observation from the Certificate of Analysis above.

CAS Number1627580-64-6
Molecular FormulaC101H152N28O22S2
Molecular Weight2174.6 g/mol
SequenceMitochondrial-derived 16-amino-acid peptide (MRP encoded in 12S rRNA)
≥99% HPLC sourcing specThird-party CoA where on fileResearch use only

MOTS-c price per mg

MOTS-c sizes, single-vial and pack prices, price per mg, lot number, measured HPLC purity and Certificate of Analysis link
Size1-vial pricePack prices$/mgLot #Measured HPLC %CoA
10mg$45.00
  • 3 Pack: $120.00 ($40.00/vial)
  • 5 Pack: $175.00 ($35.00/vial)
  • 10 Pack: $300.00 ($30.00/vial)
$4.50PX-L91699.19%CoA PDFVerify at lab
20mg$65.00—$3.25Pending CoAPending CoAPending CoA
40mg$100.00—$2.50Pending CoAPending CoAPending CoA

$/mg is the single-vial price divided by the labeled mg per vial. Lot and measured HPLC are listed only when that size's own Certificate of Analysis is on file. All certificates are in the lab results index. For laboratory research use only.

MOTS-c Specifications

MOTS-c (CAS 1627580-64-6) is studied in in-vitro and animal models via Mitochondrial Open Reading Frame of the 12S rRNA Type-C. This section covers the composition and analytical specification data. Analytical standard: ≥99% by HPLC. Stocked material is for laboratory research use only. Identity, structure, and handling values come from the existing profile.

Identity, purity and storage specifications for MOTS-c.
CompoundMOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C)
CAS1627580-64-6
Molecular formulaC101H152N28O22S2
Molecular weight2,174.6 Da
SequenceMRWQEMGYIFYPRKLR
Purity≥99% HPLC specification
FormLyophilized powder
Storage (lyophilized)-20°C, desiccated, protected from light
Storage (reconstituted)2–8°C, use within 14–28 days

Reconstituting MOTS-c: step-by-step peptide reconstitution guide. Concentration maths: peptide reconstitution calculator.

Buying MOTS-c — Frequently Asked Questions

What purity standard does Peptide.Express use for MOTS-c?

Sourced to a ≥99% HPLC specification. Where a certificate reports a mass, compare it with the 2,174.6 Da mass. Mass confirmation is worth checking on the CoA — MOTS-c is sometimes confused with humanin and other mitochondrial-derived peptides, which have different masses entirely.

Where is the Certificate of Analysis for MOTS-c?

On this page and in the Peptide.Express lab results library. Sourced against a ≥99% HPLC purity specification. Third-party Certificates of Analysis are published where on file.

What testing does MOTS-c undergo before shipping?

Where a certificate is on file, it shows the assays that laboratory reported. Those can include reverse-phase HPLC, LC-MS/MS, an endotoxin result, and visual QC. A missing line is not a pass and is not proof the assay never ran.

How should MOTS-c be stored before and after reconstitution?

Lyophilized at -20°C, desiccated and protected from light, stable for 24 months. Reconstituted at 2–8°C for 14–28 days. Aliquot before freezing if repeated access is needed — the two methionine residues and the tryptophan are oxidation-prone, which makes this peptide more freeze-thaw sensitive than most.

Is MOTS-c WADA prohibited?

Yes, at all times, under section S0 of the Prohibited List covering non-approved substances. It is not FDA-approved for any human indication.

MOTS-c research reference

Research Compounds Related to MOTS-c

NAD+The substrate pool that MOTS-c-driven AMPK activation draws down.Mitochondrial Fuel StackMOTS-c and NAD+ supplied together for substrate-signal pairing studies.SS-31Cardiolipin-binding peptide addressing mitochondrial structure rather than metabolic signaling.EpithalonAEDG tetrapeptide studied in the adjacent cellular-senescence research area.

All products are sold for in vitro laboratory research use only. Not intended for human consumption, clinical use, or veterinary use. Peptide.Express makes no medical claims. Consult the published literature for research application guidance.

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