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MOTS-c — Research Peptide

MOTS-c at a glance

Peptide.Express MOTS-c (CAS 1627580-64-6) starts at $45, ≥99% pure by HPLC, with a molecular weight of 2174.6 Da and molecular formula C101H152N28O22S2, third-party tested with a lot-matched Certificate of Analysis you can verify before purchase. Ships same day on US orders placed before 2 PM EST, free over $150. For in-vitro laboratory research use only.

MOTS-C — research-grade lyophilized peptide vial from Peptide.Express, ≥99% HPLC purity
≥99% PurityUS SynthesizedIn Stock

For laboratory research use only. Not for human or veterinary use.

Research-Grade Compound

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino-acid peptide encoded within mitochondrial DNA — specifically translated from a short open reading frame in the 12S ribosomal RNA gene, MT-RNR1. Amino acid sequence: MRWQEMGYIFYPRKLR. Molecular formula C101H152N28O22S2, molecular weight 2,174.6 Da, CAS 1627580-64-6.

Purity standard: MOTS-c is sourced to ≥99% by HPLC — sourcing spec.

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10mg · $45.00/vial

$45.00$80.00USD / Unit
1

Certificate of Analysis

Showing CoA for 10mg.

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HPLC VerifiedIdentity & purity
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MOTS-c mitochondrial peptide research guide →

In-depth research overview, mechanism of action, and study applications.

Showing CoA for 10mg
Certificate Details
Purity≥99%
Methodology
HPLCLC-MS/MS
CAS Number1627580-64-6
Molecular FormulaC101H152N28O22S2
Molecular Weight2174.6 g/mol
SequenceMitochondrial-derived 16-amino-acid peptide (MRP encoded in 12S rRNA)
Verify Results with Testing Laboratory

Issued by an independent third-party laboratory; Peptide.Express does not test in-house. Results are reproduced as-is and confirm compound identity, purity, and the analytical methods used. For questions about specific results, contact support@peptide.express.

Safety Data Sheet (SDS)
≥99% by HPLCLC-MS/MS VerifiedCoA Every BatchIn-Vitro Research Use Only

MOTS-c Specifications

Identity, purity and storage specifications for MOTS-c.
CompoundMOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C)
CAS1627580-64-6
Molecular formulaC101H152N28O22S2
Molecular weight2,174.6 Da
SequenceMRWQEMGYIFYPRKLR
Purity≥99% by HPLC
FormLyophilized powder
Storage (lyophilized)-20°C, desiccated, protected from light
Storage (reconstituted)2–8°C, use within 14–28 days

Reconstituting MOTS-c: step-by-step peptide reconstitution guide. Concentration maths: peptide reconstitution calculator.

Buying MOTS-c — Frequently Asked Questions

What purity standard does Peptide.Express use for MOTS-c?

≥99% by reverse-phase HPLC, with LC-MS/MS confirming the 2,174.6 Da mass. Mass confirmation is worth checking on the CoA — MOTS-c is sometimes confused with humanin and other mitochondrial-derived peptides, which have different masses entirely.

Where is the Certificate of Analysis for MOTS-c?

On this page and in the Peptide.Express lab results library. Each CoA is batch-specific and lists HPLC purity, LC-MS/MS mass confirmation, endotoxin result, testing laboratory and test date.

What testing does MOTS-c undergo before shipping?

Reverse-phase HPLC for purity by area under curve, LC-MS/MS for molecular weight identity confirmation, LAL endotoxin testing, and visual QC. All performed by an independent third-party laboratory with a batch-specific Certificate of Analysis.

How should MOTS-c be stored before and after reconstitution?

Lyophilized at -20°C, desiccated and protected from light, stable for 24 months. Reconstituted at 2–8°C for 14–28 days. Aliquot before freezing if repeated access is needed — the two methionine residues and the tryptophan are oxidation-prone, which makes this peptide more freeze-thaw sensitive than most.

Is MOTS-c WADA prohibited?

Yes, at all times, under section S0 of the Prohibited List covering non-approved substances. It is not FDA-approved for any human indication.

MOTS-c research reference

Research Compounds Related to MOTS-c

NAD+The substrate pool that MOTS-c-driven AMPK activation draws down.Mitochondrial Fuel StackMOTS-c and NAD+ supplied together for substrate-signal pairing studies.SS-31Cardiolipin-binding peptide addressing mitochondrial structure rather than metabolic signaling.EpithalonAEDG tetrapeptide studied in the adjacent cellular-senescence research area.

All products are sold for in-vitro laboratory research use only. Not intended for human consumption, clinical use, or veterinary use. Peptide.Express makes no medical claims. Consult the published literature for research application guidance.

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