Buy Kisspeptin

Kisspeptin is a 54-amino acid neuropeptide encoded by the KISS1 gene, widely recognized as a critical regulator of gonadotropin-releasing hormone (GnRH) secretion and reproductive neuroendocrinology. This peptide binds to the GPR54 receptor (also known as KISS1R), a G-protein-coupled receptor that activates phospholipase C and intracellular calcium signaling pathways. Kisspeptin research has fundamentally advanced understanding of the hypothalamic-pituitary-gonadal (HPG) axis, puberty onset mechanisms, and reproductive function regulation. Researchers studying kisspeptin investigate its role as a master regulator of GnRH neuron activity.

Quality and Purity Standards

Our Kisspeptin peptide is manufactured under controlled conditions with ≥99% purity verified by HPLC analysis. Each batch undergoes comprehensive testing, including mass spectrometry for molecular weight confirmation, amino acid analysis for sequence verification, and peptide content determination. Every order includes a Certificate of Analysis documenting purity levels, identity confirmation, and batch-specific analytical data.

Research Applications and Mechanisms of Action

Kisspeptin research focuses on its role as a central regulator of the HPG axis. The mechanism involves binding to KISS1R (GPR54) on GnRH neurons, activating phospholipase C and mobilizing intracellular calcium, leading to GnRH secretion. Research applications include:

GnRH neuron activity modulation studies using electrophysiological and calcium imaging techniques
Pulsatile LH and FSH secretion dynamics in response to kisspeptin administration
Puberty onset mechanisms and developmental regulation of the HPG axis
Metabolic regulation of reproductive function and energy balance integration
KISS1/GPR54 signaling pathway analysis in hypothalamic and peripheral tissues

Technical Specifications

Amino Acid Length: 54 amino acids
Purity: ≥99% (HPLC verified)
Physical Form: Lyophilized powder
Solubility: Soluble in sterile water, saline, or standard research buffers
Storage: -20°C in dry, light-protected conditions
Shelf Life: 24 months from manufacture date

Proper Storage and Handling Guidelines

Store Kisspeptin lyophilized powder at -20°C in a desiccated, light-protected environment. For reconstitution, use sterile water or 0.9% sodium chloride solution. Store reconstituted solutions at 2–8°C and use within two to four weeks.

Frequently Asked Questions

What is Kisspeptin used for in research?
Kisspeptin is a 54-amino acid neuropeptide used in neuroendocrinology research to study GnRH secretion, HPG axis regulation, puberty onset mechanisms, and reproductive function.

What purity does Kisspeptin have?
Our Kisspeptin is verified at ≥99% purity by HPLC analysis. Each order includes a Certificate of Analysis.

References and Further Reading

Researchers can consult peer-reviewed literature on kisspeptin biology (PMID: 14645220, 18792909). All products are for research use only.