Semax

Semax is a synthetic heptapeptide analog of the ACTH(4-10) fragment, carrying a C-terminal Pro-Gly-Pro extension that slows peptidase degradation relative to the parent fragment. Its molecular formula is C37H51N9O10S with a molecular weight of approximately 813.9 Da. In laboratory settings it is used as a neuropeptide probe for studying BDNF and TrkB expression in hippocampal tissue, monoamine turnover, and neuronal response to ischemic or oxidative challenge in cell culture and rodent models. All reported findings are preclinical, and the compound is supplied for in vitro research use only.

Every lot is released against a sourcing standard of ≥99% purity by HPLC, with identity confirmed by mass spectrometry. The batch-specific Certificate of Analysis reports the measured chromatographic result for the exact lot you receive. Because Semax contains a methionine residue, the chromatogram is particularly worth reviewing: the oxidized sulfoxide impurity elutes as a separate earlier peak and its presence is the clearest indicator of degradation.

Store the lyophilized powder sealed at -20°C, protected from light and moisture, where it remains stable for roughly 24 months. Allow the vial to reach room temperature before opening so atmospheric moisture does not condense onto the powder. After reconstitution, hold solution at 2°C to 8°C for short-term use or aliquot and freeze at -20°C or below, avoiding repeated freeze-thaw cycles.

Use bacteriostatic water or sterile water for injection, adding the solvent slowly down the inner wall of the vial rather than directly onto the lyophilized cake. Swirl gently until fully dissolved. Do not vortex or shake vigorously, since the methionine residue in Semax is oxidation-sensitive and interfacial shear accelerates formation of the sulfoxide species.

Semax, CAS 80714-61-0, is available for purchase in the United States as a research chemical for laboratory use by qualified investigators and institutions. It is not approved as a drug or dietary supplement and is not sold for human or veterinary use. Buyers are responsible for compliance with the regulations of their own jurisdiction and institution.

Yes. Each Semax lot ships with a batch-specific Certificate of Analysis showing the HPLC purity result and mass spectrometry identity confirmation, and the documentation is archived for review before purchase. Match the lot number on the CoA to the number printed on your vial label.